Dr. Cihan Comba | Gynecology and Gynecologic Oncology

Assoc. Prof. Dr. Cihan Comba is a specialist in Obstetrics and Gynecology (Gynecologic Oncology), with experience in diagnosing and treating a wide range of conditions related to this field. He provides care at Istanbul Aydın University Medical Park Florya Hospital, with a focus on accurate diagnosis and evidence-based treatment to support patient health and improve quality of life.

Education

2009: Ege University Faculty of Medicine
2009-2014: Residency training in the Department of Obstetrics and Gynecology, Istanbul University Istanbul Faculty of Medicine
2016-2019: Subspecialty training in Gynecologic Oncology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences

Professional Experience

2014-2016: Yozgat Sorgun State Hospital
2019-2021: Gynecologic Oncology Clinic, Sultangazi Haseki Training and Research Hospital
2019: Observer Fellow, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center

Foreign Languages

English.

Articles Published in International Peer-Reviewed Journals

Comba C, Comba A, Yılmaz H, Erdoğan ŞV, Demir Ö. (2020). Celiac disease does not influence markers of ovarian reserve in adolescent girls. Archives of Gynecology and Obstetrics, 1–7.
Comba C, Demirayak G, Erdoğan ŞV, Karaca İ, Demir Ö, Güler O, Özdemir İA. (2020). Comparison of pain and proper sample status according to usage of tenaculum and analgesia: A randomized clinical trial. Obstetrics & Gynecology Science. DOI: 10.5468/ogs.19185.
Karaca İ, Erdoğan ŞV, Doğan K, Alay İ, İnce O, Karaca SY, Comba C, Bahçeci E, Erdoğan A, Öztürk E, Ekin M. (2020). The effects of exogenous oral micronized progesterone on first-trimester aneuploidy screening markers in women with threatened miscarriage: A matched case-control study. Journal of Maternal-Fetal & Neonatal Medicine, 33(14), 1–6. DOI: 10.1080/14767058.2020.1745175.
Karaca İ, Öztürk M, Comba C, Demirayak G, Erdoğan ŞV, Özdemir İA, Hoşgören M. (2019). Does the “equal management of equal risks” model cause overtreatment in patients with positive cervical cytology results for ASCUS/non-HPV16/18 oncogenic types? Diagnostic Cytopathology, 47(2), 105–109. DOI: 10.1002/dc.24029.
Öztürk E, İnce O, Karaca İ, Demirayak G, Comba C, Alay İ, Erdoğan ŞV, Karaca SY, Özdemir İA. (2020). The impact of concurrent HPV infections on the presentation of high-grade cervical intraepithelial lesions. Ginekologia Polska, 91(1), 6–12. DOI: 10.5603/GP.2020.0002.
Karasu AFG, Aydın S, Ateş S, Takmaz T, Comba C. (2020). Administration of rectal Cytotec versus rectal Buscopan before hysteroscopy. Minimally Invasive Therapy & Allied Technologies, 29(3), 1–5. DOI: 10.1080/13645706.2020.1748059.
Özdemir İA, Comba C, Demirayak G, Gülseren V, Erdoğan ŞV, Aslanova F, Afşar S, Güngördük K. (2019). Impact of preoperative walking on postoperative bowel function in patients with gynecologic cancer. International Journal of Gynecological Cancer, 29(8), 1311–1316. DOI: 10.1136/ijgc-2019-000633.
Comba C, Demir Ö. (2019). Why is the frequency of cervical smear abnormalities increasing in Turkey? Medical Science, 23(96), 201–204.
Demirayak G, Comba C, Özdemir İA. (2018). Laparoendoscopic single-site sentinel lymph node detection in endometrial cancer. Journal of Minimally Invasive Gynecology, 25(5), 776. DOI: 10.1016/j.jmig.2017.10.035.
Demir Ö, Comba C. (2019). Risk factors for decreased pelvic floor muscle strength: Which is more effective? Gynecology Obstetrics & Reproductive Medicine, 1–4.
Demirayak G, Özdemir İA, Comba C, Aslan Çetin B, Aydoğan Mathyk B, Yıldız M, Mihmanlı V, Karaca İ, Öztürk M, Güralp O. (2020). Comparison of laparoendoscopic single-site (LESS) surgery and conventional multiport laparoscopic (CMPL) surgery for hysterectomy: Long-term outcomes of abdominal incisional scars. Journal of Obstetrics and Gynaecology, 40(2), 217–221. DOI: 10.1080/01443615.2019.1606183.
Demirayak G, Güralp O, Yıldız M, Comba C, Mihmanlı V, Özdemir İA. (2019). Laparoendoscopic single-site hysterectomy: A single surgeon’s experience in a tertiary hospital. Gynecology Obstetrics & Reproductive Medicine, 25(2).
Ergun B, Özsürmeli M, Dündar Ö, Comba C, Kuru O, Bodur S. (2015). Changes in markers of ovarian reserve after laparoscopic ovarian cystectomy. Journal of Minimally Invasive Gynecology, 22(6), 997–1003. DOI: 10.1016/j.jmig.2015.05.001.
Demir Ö, Comba C. (2019). Investigation of the incidence of coital incontinence in incontinent women. Gynecology Obstetrics & Reproductive Medicine, 1–4. DOI: 10.21613/GORM.2019.948.
Comba C, Bastu E, Dural Ö, Yasa C, Keskin G, Özsürmeli M, Buyru F, Serdaroğlu H. (2015). Role of inflammatory mediators in patients with recurrent pregnancy loss. Fertility and Sterility, 104(6), 1467–1474. DOI: 10.1016/j.fertnstert.2015.08.011.
Comba C, Güngör Uğurlucan F, Bastu E, İyibozkurt AC, Topuz S. (2014). Persistent ascites resolving with a gonadotropin-releasing hormone agonist 18 months after hospitalization for severe ovarian hyperstimulation syndrome. Archives of Gynecology and Obstetrics, 289(1), 223–225. DOI: 10.1007/s00404-013-2940-7.
Keskin G, Bastu E, Güngör Uğurlucan F, Comba C, İyibozkurt AC, Topuz S. (2013). Diffuse peritoneal leiomyomatosis. Journal of Obstetrics and Gynaecology, 33(5), 535–536.
Vatansever D, Sözen H, İyibozkurt AC, Comba C, Yavuz E, Topuz S. (2015). Extrapulmonary lymphangioleiomyomatosis mimicking lymphoma metastatic to the uterus. Journal of Obstetrics and Gynaecology Research, 41(5), 823–827. DOI: 10.1111/jog.12628.
Karaca İ, Öztürk M, Comba C, Demirayak G, Alay İ, Erdoğan ŞV, Hoşgören M, Yaşar L. (2018). Immediate biopsy of patients with negative cervical cytology and positive non-HPV-16/18 oncogenic types. Diagnostic Cytopathology, 46(4), 326–330. DOI: 10.1002/dc.23905.
Comba C, Kalelioğlu İH, Esmer AÇ, Dural Ö, Has R, Oktar TM. (2015). Outcomes of fetuses diagnosed with megacystis in the first trimester at our clinic. Journal of Clinical Obstetrics & Gynecology, 25(1), 7–11. DOI: 10.5336/gynobstet.2014-39998.
Demir O, Kaya FM, Sal H, Ozalp M, Comba C, Aran T. (2021). Vulvar abscess as a late complication following the minimally invasive mini-sling procedure for stress urinary incontinence. European Journal of Obstetrics & Gynecology and Reproductive Biology, 256, 514–515. DOI: 10.1016/j.ejogrb.2020.10.041. Published online November 3, 2020. PMID: 33168268.
Demir O, Sal H, Comba C. (2021). Triangle of COVID, anxiety and the menstrual cycle. Journal of Obstetrics and Gynaecology, May 6, 1–5. Online ahead of print. DOI: 10.1080/01443615.2021.1907562. PMID: 33955327.
Comba C, Demirayak G, Simsek C, Atas BS, Özdemir İA. (2021). Transvaginal natural orifice transluminal endoscopic surgery (vNOTES) total retroperitoneal sentinel lymph node biopsy for an endometrial cancer patient with prior colon cancer surgery. International Journal of Gynecological Cancer, August 11, ijgc-2021-002710. Online ahead of print. DOI: 10.1136/ijgc-2021-002710. PMID: 34380707.
Comba C, Topaktas M, Bozkurt H, Erbin A, Ozdogan B, Demir O. (2021). Vaginal cancer as a late complication of radiotherapy for endometrial cancer and ileo-perineal fistula after total pelvic exenteration. Journal of Gynecologic Oncology, 32(4), e63. DOI: 10.3802/jgo.2021.32.e63. PMID: 34085797. PMCID: PMC8192226.

International Conference Presentations Published in Proceedings

Güngördük K, Demirayak G, Comba C, Özdemir İA. (2018). Laparoscopic management of a patient with vaginal cancer. 6th International Video Workshop on Radical Surgery in Gynecologic Oncology. Conference abstract.
Bastu E, Comba C, Özsürmeli M, Yasa C, Dural Ö, Serdaroğlu H. (2013). Role of inflammatory mediators in cells of patients with recurrent miscarriage. American Society for Reproductive Medicine (ASRM), 69th Annual Meeting, 1(1), 304. Conference abstract.
Comba A, Comba C, Erdoğan ŞV. (2018). Changes in ovarian function tests in a patient with childhood celiac disease. 12th Turkish-German Gynecological Association Congress, 12(1), 39. Conference abstract.
Comba C, Demirayak G, Bahçeci E, Erdoğan ŞV, Özdemir İA. (2017). A signet cell tumor of the ovary diagnosed after treatment of Hodgkin lymphoma: The first case in the literature. 25th European Congress of Obstetrics and Gynaecology, held jointly with the 15th Congress of the Turkish Society of Obstetrics and Gynecology.
Comba C. (2018). Laparoscopic pelvic lymphadenectomy: My technique. Minimally Invasive Gynecologic Surgery Congress. Conference abstract.
Dural Ö, Güngör Uğurlucan F, Yasa C, Bastu E, Comba C, Özsürmeli M, Can S. (2014). Nerve-sparing clitoral reduction in a 23-year-old patient with congenital adrenal hyperplasia. 12th National Congress of Gynecology and Obstetrics and 6th Congress of the Mediterranean Federation of Obstetrics and Gynecology. Conference abstract.

Book Chapters

Vaginal Estrogen Therapy in Women with Breast Cancer
Demir Ö, Comba C. (2019). In Current Studies in Obstetrics and Gynecology II.
Editor: Süleyman Cansun Demir. Akademisyen Publishing, 1st edition. Book length: 173 pages.
ISBN: 978-605-258-565-8. Academic book in Turkish.
Surgical Treatment of Cervical Cancer in Light of the 2018 International Federation of Gynecology and Obstetrics (FIGO) Staging System
Comba C. (2019). In Current Studies in Obstetrics and Gynecology II.
Editor: Süleyman Cansun Demir. Akademisyen Publishing, 1st edition. Book length: 173 pages.
ISBN: 978-605-258-565-8. Academic book in Turkish.
Contraception
Comba C, Bastu E. (2013). In Handbook of Gynecology.
Editors: Abdullah Turfanda, Ahmet Büyükören, Ahmet Cem İyibozkurt, Funda Güngör Uğurlucan, Ercan Bastu, Cenk Yasa and Özlem Dural. Nobel Medical Publishing, 1st edition. Book length: 148 pages.
ISBN: 978-975-420-980-8. Academic book in Turkish.
Postoperative Fever
Comba C, Demir Ö, Dural Ö. (2013). In Handbook of Gynecology.
Editors: Abdullah Turfanda, Ahmet Büyükören, Ahmet Cem İyibozkurt, Funda Güngör Uğurlucan, Ercan Bastu, Cenk Yasa and Özlem Dural. Nobel Medical Publishing, 1st edition. Book length: 148 pages.
ISBN: 978-975-420-980-8. Academic book in Turkish.
Septic Shock
Comba C, Sırma R, Turfanda A. (2013). In Handbook of Gynecology.
Editors: Abdullah Turfanda, Ahmet Büyükören, Ahmet Cem İyibozkurt, Funda Güngör Uğurlucan, Ercan Bastu and Cihan Comba. Nobel Medical Publishing, 1st edition.
ISBN: 978-975-420-980-8. Academic book in Turkish.
Hirsutism
Comba C, Bastu E. (2013). In Handbook of Gynecology.
Editors: Abdullah Turfanda, Ahmet Büyükören, Ahmet Cem İyibozkurt, Funda Güngör Uğurlucan, Ercan Bastu, Cenk Yasa and Özlem Dural. Nobel Medical Publishing, 1st edition. Book length: 148 pages.
ISBN: 978-975-420-980-8. Academic book in Turkish.

Articles Published in National Peer-Reviewed Journals

Karasu AFG, Sönmez FC, Turan H, Comba C, Turna S, Arıcı DS. (2020). Survivin and Ki-67 expression in leiomyomas, leiomyoma variants, leiomyosarcoma, and STUMP: An immunohistochemical and clinical follow-up study. Annals of Medical Research, 27(2), 557–562. DOI: 10.5455/annalsmedres.2019.12.824.
Özsürmeli M, Bastu E, Comba C, Sucu M, Arslan E, Mısırlıoğlu S, Çelik F, Zeybek ŞÜ, Büyükören A. (2019). Changes in inflammatory markers and adhesion molecules in women using oral contraceptives. Cukurova Medical Journal, 44(2), 561–566. DOI: 10.17826/cumj.442138.
Comba C. (2018). When should obstetricians and gynecologists perform endometrial biopsy in patients with vaginal bleeding or menometrorrhagia? Bakırköy Medical Journal, 14(2), 242–246. DOI: 10.5350/BTDMJB.20180507024054.
Balkan B, Demirayak G, Comba C, Yener YZ, Hergünsel GO, Özdemir İA. (2020). Comparison of epidural and intravenous routes for acute and chronic postoperative pain control in patients with gynecological malignancy. Ağrı, 32(2), 91–98. DOI: 10.14744/agri.2019.26986.
Güngör Uğurlucan F, Comba C, Emeğil Ş, Yalçın Ö. (2017). Beliefs and attitudes regarding urinary incontinence in Turkey. Journal of Istanbul Faculty of Medicine, 79(4), 141–146. DOI: 10.18017/iuitfd.308488.

National Conference Presentations Published in Proceedings

Demir Ö, Comba C, Güngör Uğurlucan F. (2018). Treatment of a patient with secondary infertility and vaginismus. 7th Palandöken Obstetrics and Gynecology Congress.
Comba C, Demirayak G, Erdoğan ŞV, Afşar S, Özdemir İA. (2019). Diaphragmatic resection in recurrent endometrial cancer. 17th National Congress of Gynecology and Obstetrics.

Other Publications

Önder H, Comba C. (2019). A very rare case of mirror syndrome presenting with concurrent posterior reversible encephalopathy syndrome. Journal of Medical Sciences, 39(6), 284–288. DOI: 10.4103/jmedsci.jmedsci_25_19. Case report.
Comba C, Demirayak G, Erdoğan ŞV, Kahraman ZS, Özdemir İA. (2018). A signet-ring cell stromal tumor of the ovary diagnosed after treatment of Hodgkin’s lymphoma: The first case and review of the literature. Journal of Gynecologic Surgery, 34(3), 154–158. DOI: 10.1089/gyn.2017.0111. Review article.
Cengiz H, Demirayak G, Comba C, Özgün ÇG, Özdemir İA. (2018). Two-year survival of low-grade fibromyxoid sarcoma of the vulva managed by surgical therapy. Journal of Gynecologic Surgery, 34(6), 295–297. DOI: 10.1089/gyn.2017.0132. Case report.
Demir Ö, Comba C. (2019). Treatment of a woman with secondary infertility and vaginismus. Medical Sciences, 23(96), 195–199. Case report.
Yasa C, Dural Ö, Demiral İ, Comba C, Demir Ö, Bastu E. (2016). Torsion of a pedunculated subserous leiomyoma in a pregnant woman: A rare case report. International Surgery, 101(2). DOI: 10.9738/INTSURG-D-15-00165.1. Case report.
Demir Ö, Çeliksoy HY, Comba C. (2019). Approach to scorpion stings during pregnancy: A case report. Journal of Istanbul Faculty of Medicine, 82(3), 164–167. DOI: 10.26650/IUITFD.2019.368394. Case report.